A Cohort Of Adult Egyptian Patients With Acute Myeloid...

The clinical relevance and prognostic significance of ABCG2 gene expression in a cohort of adult Egyptian patients with acute myeloid leukemia Abstract Purpose ; Acute myeloid leukemia (AML) is a genetically heterogeneous clonal disorder, with several novel prognostic factors including changes in levels of gene expression. Limited number of clinical studies are available about the role of multidrug transporter adenosine triphosphate–binding cassette protein (ABCG2) gene expression in adult AML. Methods; In this study we measured ABCG2 mRNA expression by quantitative real time RT-PCR in 50 de novo adult AML patients and 20 healthy normal controls. We evaluated the of expression in relation to other clinical and prognostic factors, response to treatment and disease free survival in AML patients to investigate their possible association with clinical outcomes. ABCG2 mRNA was over expressed in AML patients than in control. Results; There was a positive correlation between ABCG2 gene expression level and the percent of CD34expression (p= 0.016, r= 0.330). There was no statistically significant relation between ABCG2 mRNA expre ssion level and response to induction treatment as well as disease free survival of the studied group of patients. Conclusion; ABCG2 m-RNA is over expressed in AML ,but it did not affect the prognosis of the patients. The biology of ABCG2 expression and function in AML is more complex and needs more standardized clinical studies. Key words; ABCG2,