Presentation Architecture in Renaissance and Baroque Essay Example for Free

Presentation Architecture in Renaissance and Baroque Essay All aspects of Renaissance culture, from art and architecture to philosophy, were influenced and inspired by Ancient Greek and Roman civilizations. Generally, architecture in the Renaissance can be described as symmetrical, harmonious and sober. Many buildings that were built in the Renaissance are perfect symmetrical, if you would draw a line through the middle of the building, it would have two exact same halves. Because it is so symmetrical, it looks very harmonious and static. However, it often also looks authorative probably because of the use of pediments and columns which make it look like Grecian temples. Renaissance buildings are rarely very high or vertical in contrast to buildings in Gothic architecture. Furthermore, architecture in the Renaissance was very much about the details. On many buildings, you can see lintels, which are the things above the window and you can also often see small sculptures of men, women, gods or other important people. The most important characteristic of the Renaissance is that shapes from the Greek and Roman times were reused in new designs. Typical characteristics that returned in many designs are: columns, which are vertical pillars, pilasters, which is almost the same as a column except that a pilaster is connected to the wall sticking out and it is used as a decoration, vaults, which are arched roofs that support the weight of a roof, domes, which is a hollow sphere above a building and arches, which are structures that span a space while supporting weight, such as a doorway or window in a wall. This is one example of a villa built in Renaissance style. The architect was Palladio, who designed the building in 1567. Palladio was asked to build a villa for Paolo Almerica, a high functionary of the Pope. Villa Almerica is better known as La Rotonda. It was used as a location for parties as well as a place to live in. It is made up of a cube centre part, where the owners of the villa lived, with on the 4 sides of the building the same set of columns and entablature built to it. In this picture, you can see that this building has a dome, pilasters, lintels and columns with Ionic capitals, which you can see here. A capital is the top of a column. It also has an entablature with a cornice and the architrave. The two middle columns are placed a bit  to the sides to emphasize the door. This part looks a bit like a Grecian temple and that makes it look authorative. Another example of a building made in the Renaissance is The Tempietto del San Pietro. It is a cylinder-shaped little church in Rome. The word â€Å"tempietto† means â€Å"small Temple† as it is one. The Tempietto is built at the court of the San pietro in Montorio church. It was built by Donato Bramante in 1502. The Spanish king Ferdinand ordered Bramante to build a church to remember the crucifixion of Petrus, one of the first apostles and the first pope. The little temple would be built on the spot where Petrus was crucified. This is why the building is especially important in Rome. As you can see it looks very Greek again because of the columns with doric capitals. It also has a dome but it especially looks Greek because of the symmetry of the temple. The building expresses the balanced proportions of Renaissance architecture. The columns, the frieze and the decorative features all show the classical influence. At the end of the 17th century, Baroque rose up and started to replace the Renaissance. This change was due to religious reasons. In the 1500s the Roman Catholic Church was under much pressure to reform. In this period, Protestantism was rising, especially in northern Europe. Protestantism was highly critical of the Roman Catholic Church and its abuses of its powerful position. Baroque can be seen as a cultural public relations movement started by the Roman Catholic Church to win back the support of the people. Protestantism is characterized by sober architecture. The roman-Catholics decided to go the opposite direction and promote architecture which was over the top, dramatic and extraordinary, to try and get the public back to re-interest in the Roman Catholic Church again. Baroque is an architectural style, which evolved in the 16th century in Italy. During the 17th century, the style spread through Europe and Latin America. Baroque architecture is the opposite of Renaissance architecture. Renaissance architecture was very calm and balanced, symmetrical and harmonious while the baroque architecture was very extravagant and asymmetrical. Baroque style is all about drama, energy and rhythm. The  grandiose buildings, sculptures and paintings were meant to inspire religious awe and excitement in the people. The Baroque architecture draws your attention. Baroque style is typical for breaking the limits for classic buildings and going in an extreme form. Most baroque buildings have bent asymmetrical shapes. Baroque architecture buildings are supposed to amaze people. It is supposed to look fantastic and over the top. Some people might think it is kitsch. This is a picture of a kaisersal residence, which was used from 1719 to 1944. Johann Balthazar Neumann was the architect who designed this baroque style house for the Prince Bishops of Wuerzburg. In this room, the Bishop received important people. The over the top theme of baroque is shown in this room by the amount of decoration. It is really overwhelming because of all the gold and the decorations. You can see that this room was designed to receive important people as it would impress them. You can’t recognize any Renaissance architecture features in this room anymore. You can’t see any Ancient Greek or Roman architectural features. This is another example of Baroque architecture. It is the Berlin Cathedral or Berliner Dom in Berlin, Germany. It is also called the Lutheran Cathedral. The people who went to Berlin might recognize it. Again, you can see that it is very extravagant and over the top. It has many details and decorative features such as all the sculptures. This building has some Renaissance features though such as the pilasters and the pediments and off course the domes. The baroque spread through Europe but didn’t really spread in this form to northern Europe because Protestantism was too strong there. In Holland, which was also very protestant, the Baroque style developed in its own way. It had such a distinctive style that it got a different name: Dutch Classicism or Hollands Classicisme. It glorified the Dutch Republic of the 17th century, democracy and the new found wealth from colonialism.

Flawed Characters of Young Goodman Brown, Rappaccinis Daughter, and The Birthmark :: Young Goodman Brown YGB

Flawed Characters of Young Goodman Brown, Rappaccini's Daughter, and The Birthmark      Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   In many of Nathaniel Hawthorne's short stories, he creates characters with either a malicious or evil feature to relay to the reader a more allegorical meaning.   Many would say he targets woman without justification. Therefore a reader may interpret him to be a misogynist.   In the story " Rapaccinni's Daughter" he uses Beatrice as a carrier of a deadly poison.  Ã‚   In " Young Goodman Brown" he targets Faith as the character who is lost to the Devil. In the stories "Rappaccini's Daughter," and "The Birthmark," Hawthorne also uses men as transmitters of evil illicitly.   The men involved in the stories have their own flaws which contribute to the flaws of the women in their lives. Ultimately, Hawthorne in the cases above can be seen as a misogynist who directs his maliciousness on only women, yet he also uses male characters as vile transmitters of evil, therefore he is not a misogynist and targets both sexes equally.      Ã‚  Ã‚  Ã‚  Ã‚   In Young Goodman Brown, Faith, the wife of Young Goodman Brown is a character who loses her faith and submits to the Devil.   Hawthorne, in this case directly uses faith as the carrier of a flaw.   That is, she does not contain enough self-control, or faith to refuse the calling of the Devil.   Even with the emotional plea from her husband, "Look up to heaven, and resist the wicked one," (1590)   Faith cannot resist the Devil's temptation and has "uncertain sorrow," (1587) after submitting to him.  Ã‚   The character of Faith which Hawthorne portrays is one of uncertainty and one which has a lack of self control.   Faith is a good example of how Hawthorne uses a woman to symbolize a deeper significance, in this case, it is to evoke the hypocrisy of the Puritan people, that is, Puritans are really not as pure as we all think, they also contain evil characteristics, in this case, exploited at night. We cannot justify Hawthorne's usage of   Faith as misogyny, in that woman were not considered equal in status to men in the early 16th and later centuries.   Also, with the history of witchcraft during the puritan era, it can be seen appropriate that Hawthorne

Extraction and Evaporation Recrystallization Essay

1. To the components of a simulated pharmaceutical preparation, Panacetin, and identifying the unknown component of the mixture through extraction and separation methods. 2. To learn how to purify by recrystallization, how to dry them and how to obtain a melting point. PRECAUTION: ACETANILIDE AND PHENACETIN ARE EYE AND SKIN IRRITANTS. Minimize contact with your unknown compound. THEORY: In this experiment, Panacetin, a pharmaceutical preparation will be separated from its components by making use of their solubilities and acid-base properties. Panacetin contains aspirin, sucrose and an unknown component that may be either acetanilide or phenacetin. Of the three components, only sucrose is insoluble in the organic solvent dichloromethane (CH2Cl2 or methylene chloride). The insoluble sucrose can be filtered out if Panacetin is dissolved completely in dichloromethane by gravity filtration or centrifugation leaving the soluble aspirin, acetanilide and phenacetin in the solution. Although the acetanilide and aspirin are both quite insoluble in water at room temperature, the sodium salt of aspirin is very soluble in water but insoluble in dichloromethane. Aspirin, which is a strong acid can be converted to the salt, sodium acetylsalicylate by extraction with an aqueous solution of sodium bicarbonate . This salt will migrate from the dichloromethane layer, in which it is insoluble, to the aqueous layer, in which it is soluble. The unknown component will stay behind in the solution  and can be isolated by evaporating the solvent from the dichloromethane solution. Adding HCl to the aqueous solution restores aspirin as an insoluble white solid. In the third experiment, the identity of the unknown component of Panacetin will be purified. Purification is necessary because the separation procedure may be imperfect leaving traces of small quantities in the compound after separation or chemical reactions may occur prior to or during the separation adding new impurities. The unknown component can be purified by recrystallization, in which an impure solid dissolves in a hot (usually boiling) solvent then crystallizes from the cooled solution in a purer form. METHODS/PROCEDURES: This experiment was followed from the textbook on pages 52-53 for experiment 2 and 59-60 for experiment 3 excluding the microscale part. First, weigh approximately 3.00 g of Panacetin and transfer it to a clean, dry 125 ml Erlenmeyer flask. Add 50 ml of dichloromethane to the flask , stir the mixture with a stirring rod to break up any lumps. When it appears that no more of the solid will dissolve, filter the mixture by gravity. Collect the undissolved solid on the filter paper and set it aside to dry. Once it has completely dried, reweigh the solid. This compound separated by gravity  filtration is known as sucrose. Next, transfer the filtrate to a separatory funnel and extract it with two 30 ml portions of 5% sodium bicarbonate . For each extraction, use a stirring rod to stir the liquid layer until any fizzing subsides before a stopper is placed on the funnel and shaken. Dichloromethane will be on the bottom layer and will be drained to a different container. Transfer the dichloromethane layer back into the funnel for the second extraction. The upper layer will be transferred in an Erlenmeyer flask and will be used for recovery of acetanilide. Combine the two aqueous solutions in the same container and acidify slowly with 6M HCL to bring it to a pH of 2. Cool the mixture to room temperature or below while swirling the flask occasionally in an ice bath. Collect the aspirin by vacuum filtration. Wash the aspirin on the filter with cold distilled water. Dry the sample thoroughly before weighing and leave it in the hood for the next lab schedule. Before proceeding to recrystallization, triturate the compound with 20 ml of hexane. Crush the solid with a stirring rod and filter. Recrystallize the unknown drug component from experiment 2 by boiling it with just enough water to dissolve it completely, then letting it cool to room temperature then to 0 C. In order to induce crystallization, it would be helpful to scratch the walls of the flask so that crystals would have a surface to attach to. Use vacuum filtration to isolate the sample then dry the product to a constant mass and weigh in a tared vial. Grind a small amount of the dry unknown component to a fine powder on a watch glass using a spatula. Divide the solid into four equal portions. Combine portions 1 and 2. Mix portion 3 with an approximately equal amount of finely ground acetanilide and mix portion 4 with an approximately equal amount of finely ground phenacetin. Obtain the melting point ranges of the purified unknown (portions 1 and 2), mixture with acetanilide and mixture with phenacetin. Each melting point should be measured on two samples- more than that if melting points are imprecise or accurate. Safety Issues: (all of these are taken from MSDSonline.com) 1. Acetanilide Potential Acute Effects: Hazardous in case of eye contact (irritant), of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant). Potential Chronic Health Effects: Hazardous in case of eye contact (irritant), of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant). 2. Phenacetin Eye and skin irritant 3. Dichloromethane Potential Health Effects Inhalation: Causes irritation to respiratory tract. Has a strong narcotic effect with symptoms of mental confusion, light-headedness, fatigue, nausea, vomiting and headache. Causes formation of carbon monoxide in blood which affects cardiovascular system and central nervous system. Continued exposure may cause increased light-headedness, staggering, unconsciousness, and even death. Exposure may make the symptoms of angina (chest pains) worse. Ingestion: May cause irritation of the gastrointestinal tract with vomiting. If vomiting results in aspiration, chemical pneumonia could follow. Absorption through gastrointestinal tract may produce symptoms of central nervous system depression ranging from light headedness to unconsciousness. Skin Contact: Causes irritation, redness and pain. Prolonged contact can cause burns. Liquid degreases the skin. May be absorbed through skin. Eye Contact: Vapors can cause eye irritation. Contact can produce pain, inflammation and temporal eye damage. Chronic Exposure: Can cause headache, mental confusion, depression, liver effects, kidney effects, bronchitis, loss of appetite, nausea, lack of balance, and visual disturbances. Can cause dermatitis upon prolonged skin contact. Methylene chloride may cause cancer in humans. Aggravation of Pre-existing Conditions: Persons with pre-existing skin disorders, eye problems, impaired liver, kidney, respiratory or cardiovascular function may be more susceptible to the effects of this substance. 4. Aspirin Eye Contact: Moderate Eye Irritation: Signs/symptoms may include redness, swelling, pain, tearing, and blurred or hazy vision. Skin Contact: Moderate Skin Irritation: Signs/symptoms may include localized redness, swelling, itching, and dryness. May be absorbed through skin and cause target organ effects. Inhalation: No health effects are expected. Ingestion: May be harmful if swallowed. Gastrointestinal Irritation: Signs/symptoms may include abdominal pain, nausea, diarrhea and vomiting. Repeated ingestion may cause: May be absorbed following ingestion and cause target organ effects. Target Organ Effects: Prolonged or repeated exposure may cause: Auditory Effects: Signs/symptoms may include hearing impairment, balance dysfunction and ringing in the ears. Clotting Disorders: Signs/symptoms may include increased blood clotting time and internal bleeding (hemorrhage). Liver Effects: Signs/symptoms may include loss of appetite, weight loss, fatigue, weakness, abdominal tenderness and jaundice. Central Nervous System (CNS) Depression: Signs/symptoms may include headache, dizziness, drowsiness, incoordination, nausea, slowed reaction time, slurred  speech, giddiness, and unconsciousness. Kidney Effects: Signs/symptoms may include reduced or absent urine production, increased serum creatinine, lower back pain, increased protein in urine, and increased blood urea nitrogen (BUN). Pulmonary Edema: Signs/symptoms may include chest discomfort, shortness of breath, significant cough with frothy sputum production, bluish colored skin (cyanosis), increased heart rate, respiratory failure and may be fatal. Single exposure may cause: Immunological Effects: Signs/symptoms may include alterations in the number of circulating immune cells, allergic skin and /or respiratory reaction, and changes in immune function. 5. Sodium Bicarbonate EMERGENCY OVERVIEW Warning! May cause respiratory tract irritation. Causes eye and skin irritation. Target Organs: Blood, kidneys, heart, liver, eyes, skin. Potential Health Effects Eye: Causes eye irritation. Skin: Causes skin irritation. May be harmful if absorbed through the skin. Ingestion: May be harmful if swallowed. Causes gastrointestinal tract irritation. Inhalation: May cause respiratory tract irritation. May be harmful if inhaled. Chronic: May cause liver and kidney damage. Adverse reproductive effects have been reported in animals. Laboratory experiments have resulted in mutagenic effects. Chronic exposure may cause blood effects. 6. Hydrochloric Acid POTENTIAL HEALTH EFFECTS: Inhalation: May cause irritation (possibly severe), chemical burns, and pulmonary edema. Skin contact: May cause irritation (possibly severe) and chemical burns. Eye contact: May cause irritation (possibly severe), chemical burns, eye damage, and blindness. Ingestion: Not a likely route of exposure. Target Organs Effected: Respiratory System, Skin, Eye Chronic Effects: Repeated or prolonged exposure to dilute solutions may result in dermatitis. Discoloration of the teeth may occur as a result of long term exposure. Interaction with Other Chemicals Which Enhance Toxicity: None known Medical Conditions Aggravated by Exposure: None known OBSERVATIONS/RESULTS: In Experiment 2, the extraction of substances from one another is based on the differences in their physical and chemical properties. Approximately, 3.0029 g of panacetin was weighed and completely dissolved in 50 ml of dichloromethane and filtered. The residue was left to dry and weighed (sucrose). Then 30 ml of NaHCO3 was added to the filtrate. This solution was transferred into a separatory funnel. This formed two layers. Top layer was the organic layer (NaHCO3) described as a clear liquid. Bottom layer was the aqueous layer and was yellow in color. The filtrate was washed twice with NaHCO3. HCl was added to the aqueous solution until the pH equaled to 2.0. It was filtered through vacuum filtration and allowed to dry until the next week’s lab. This filtrate is known as aspirin. Meanwhile, the unknown in the organic layer was also allowed to settle for the next experiment. In experiment 3, before we went to do recrystallization, we first did trituration of the unknown by adding 20 ml of hexane. We crushed the solid and filtered. Even with the addition of approximately 27 ml of boiling water into the compound, it started to dissolve. That was the first clue that we have acetanilide as our unknown. We went ahead and continue heating and swirling the solution over a hot plate. There was the formation of brown oil-like globules. We were then asked to decant the clear liquid from this solution. This clear liquid was allowed to cool to room temperature then to 0 C. There was formation of white crystals at the edge of the beaker. Through vacuum filtration, we were able to filter the product, weighed and used for melting point measurement of the unknown. The solid was divided into 4 equal parts. First 2 parts were combined, 3rd part was mixed with acetanilide and the last part was mixed with phenacetin. After taking the melting points of all these 3 substances we were able to identify the unknown product to be acetanilide. No big issues encountered during this experiment. Transferring some products as well as the final crystals from watch glass and filter paper and leaving some products were crucial to get the most final product. This explains why the percent recovery for the unknown was low. Some crystals fell off or didn’t transfer to the filter paper. Even though the % recovery was relatively low (88.4079%), this experiment still produced a 0.6898 g of product. DISCUSSION/CONCLUSION: This experiment was focused on two main objectives. First, the analysis of panacetin to find out what percentages of sucrose, aspirin and the unknown component it contains. Second, to find out whether the unknown is acetanilide and phenacetin. A big part of the composition of panacetin was made up of the unknown. We were able to determine the composition of sucrose to be 17.95 %, Aspirin 26.93% and the unknown to be 55.12% After following the experiment procedures, we were able to purify through recrystallization the end product to be acetanilide. This is an odorless white crystalline solid substance which has a melting point of 114 C. Our experimental value for acetanilide’s melting point was 117 which indicates that the result had a very narrow range and close to the literature value. I would therefore conclude that we had isolated a close to pure product of acetanilide with little impurities present. 1. a. Describe any evidence that a chemical reaction occurred when you added 6 M HCl to the solution of sodium acetylsalicylate A chemical reaction took place upon the addition of 6M HCl to a solution of sodium acetylsalicylate because a precipitate formed known as aspirin. b. Explain why the changes that you observed took place. The observed change took place as a result of the acid reacting with the salt forming a compound insoluble in water. 2. Describe any explain the possible effect on your results of the following experimental errors or variations. In each case, specify the component (s) whose percentage(s) would be too high or too low. a. After adding dichloromethane to Panacetin, you didn’t stir or shake the mixture long enough Improper stirring or shaking of the mixture will result in incomplete dissolution of the panacetin mixture. There will be loss of some solid analytes during filtration. The recovered amounts will be lower than they should be leading to a final percentage to be low. b. During the NaHCO3 extraction you failed to mix the aqueous and organic layers thoroughly. If the aqueous and organic layers were not thoroughly mixed the acid would remain in the solution and the extraction would be less efficient resulting to a low percentage yield. c. You mistakenly extracted the dichloromethane solution with 5 % HCl rather than 5 % NaHCO3. If 5% HCl is used instead of 5% NaHCO3 that would protonate the aspirin and keep it in the organic solution making the aspirin, acetylsalicyclic acid. d. Instead of using pH paper, you neutralized the sodium bicarbonate solution to pH 7 using litmus paper At ph7 the bicarbonate wouldn’t be able to act as a base and extract a proton because at pH of 7 it would protonate itself so it wouldn’t be able to react with aspirin. 5. Write a balanced reaction equations for the reactions involved a. When aspirin dissolves in aqueous NaHCO3 C9H8O4 (aq) + NaHCO3 (aq) —–> C9H7O4Na (aq) + CO2 + H2O Weak acid weak base Strong Base Strong acid b. When Aspirin is precipitated from a sodium acetylsalicylate solution by HCL C9H7O4Na + HCl ————-ËÆ' C9H8O4 + NaCl Strong Base Strong acid Weak Acid Weak Base Assuming that both reactions are spontaneous under the standard conditions, label the stronger acid, stronger base, weaker acid and weaker base in each equation. Experiment 3 1. a. What is the minimum volume of boiling water needed to dissolve 0.200 g of phenacetin? b. About how much phenacetin will remain dissolved when the water is cooled to room temperature? c. Calculate the maximum mass of solid (undissolved) phenacetin that can be recovered when the cooled solution is filtered. 0.200 g-0.0125 g (amount soluble in cold water)= 0.1875 g 2. An unknown compound X is one of the four compounds listed in table 3.2. A mixture of X with benzoic acid melts at 89 C, a mixture of X with phenyl succinate melts at 120  °C and a mixture of X with m-aminophenol melts at 102  °C. Give the identity of X and explain your reasoning. X is phenyl succinate. When a compound mixes with a different compound, the melting point of the mixture will be lower than the melting points of either of the pure compounds. Basing from the table, the melting point of pure benzoic acid is 121 C but when mixed to X, it went down to 89 C. Likewise with O-toluic acid and m-aminophenol. Since the melting point of mixture X with phenyl succinate has a melting point of 120 C, the melting point of pure X must be equal or closer to 121. Mixing X with phenyl succinate did not change the melting point thus X must be phenyl succinate.

A Cohort Of Adult Egyptian Patients With Acute Myeloid...

The clinical relevance and prognostic significance of ABCG2 gene expression in a cohort of adult Egyptian patients with acute myeloid leukemia Abstract Purpose ; Acute myeloid leukemia (AML) is a genetically heterogeneous clonal disorder, with several novel prognostic factors including changes in levels of gene expression. Limited number of clinical studies are available about the role of multidrug transporter adenosine triphosphate–binding cassette protein (ABCG2) gene expression in adult AML. Methods; In this study we measured ABCG2 mRNA expression by quantitative real time RT-PCR in 50 de novo adult AML patients and 20 healthy normal controls. We evaluated the of expression in relation to other clinical and prognostic factors, response to treatment and disease free survival in AML patients to investigate their possible association with clinical outcomes. ABCG2 mRNA was over expressed in AML patients than in control. Results; There was a positive correlation between ABCG2 gene expression level and the percent of CD34expression (p= 0.016, r= 0.330). There was no statistically significant relation between ABCG2 mRNA expre ssion level and response to induction treatment as well as disease free survival of the studied group of patients. Conclusion; ABCG2 m-RNA is over expressed in AML ,but it did not affect the prognosis of the patients. The biology of ABCG2 expression and function in AML is more complex and needs more standardized clinical studies. Key words; ABCG2,